Marcelo D. Carattino, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Molecular basis of function of acid sensing ion channels/epithelial sodium channel proteins.
Organization and regulation of the urothelial tight junction barrier in health and disease states.
Does urothelial barrier dysfunction contribute to pain and altered bladder function in interstitial cystitis?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Acid sensing ion channels; claudins; tight junctions; epithelial transport; interstitial cystitis

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Structure function studies of ion channels (two-electrode voltage clamp and patch-clamp)
Epithelial transport and tight junction barrier function (Ussing chambers and flux assays)
Analysis of protein expression and distribution
Analysis of urinary bladder function and bladder sensory pathways in small animals
Animal models of interstitial cystitis