Patrizia Fuschiotti, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Phenotype and functional characterization of cytokine -producing T cells in fibrotic skin and lung from patients with systemic sclerosis.
Molecular mechanisms of cytokine dysregulation in T cells from patients with systemic sclerosis.
Development of ex vivo organ skin culture to evaluate fibrosis in SSc and its inhibition.

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Human inflammatory skin diseases – Systemic sclerosis – Human T-cell differentiation – Cytokines – Fibrosis

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Cellular/molecular analyses oh human T-cell differentiation.
Human tissue-resident T-cell isolation and characterization
Biochemical/Biophysical analyses of proteins.
Ex vivo skin organ culture.
Light microscopy.