Sarah L. Gaffen, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
How does the cytokine IL-17 mediate molecular signaling?
How does IL-17 signaling mediate pathology in autoimmunity?
How does IL-17 signaling mediate host defense in fungal infections?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Th17 cells, autoimmunity, fungal immunity, cytokines, inflammation

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
IL-17 signaling in tissue culture systems
Mouse models of Candida albicans infection
Mouse models of psoriasis
Molecular signaling assays (western blotting, ChIP, immunoprecipitation, luciferase assays, RNA isolation and analysis, genetic engineering, transfection)
Flow cytometry