Deborah L. Galson, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
How does the interaction between measles nucleocapsid protein signaling and genetic factors induce Paget’s disease of bone?
Can we identify novel molecular modulators in the bone microenvironment involved in regulating osteoclast and osteoblast functions that impacts myeloma cell cross-talk with the bone?
Can we develop novel therapeutics that target the pathological bone microenvironment in multiple myeloma-induced bone disease and/or other inflammatory bone pathologies such as Paget’s disease of bone and rheumatoid arthritis?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Cancer-induced bone disease • Pathological bone microenvironment • Epigenetic chromatin structure regulation • TBK1/IKKε signaling • Gfi1 cofactors

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Myeloma and Paget’s disease of bone mouse models
Osteoclast and osteoblast differentiation and function assays in vitro and in vivo
Chromatin immunoprecipitation
Transcriptional regulation
Calvarial 3D culture models useful for cancer cell-bone microenvironment drug tests