Anthony Kanai, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Central and peripheral mechanisms involved in lower urinary tract dysfunction due to spinal cord injury and novel therapeutic options.

Mechanisms responsible for radiation cystitis and the development of agents for its treatment.

Roles of nitric oxide and guanylate cyclase in urinary bladder overactivity and the therapeutic mechanism of phosphodiesterase type-5 inhibitors.

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Bladder overactivity
P75 neurotrophin receptor modulators
PDE-5 inhibitors
Radiation cystitis
Spinal cord injury

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Afferent nerve recordings, cystometry, light-sheet microscopy, optical mapping, optogenetics