Ossama B. Kashlan, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
How do proteins in the epithelial sodium channel (ENaC) family sense their environment?

Are proteins in the ENaC family modular, i.e. do specific domains impart specific functions?

What are the biological roles of allosteric regulatory mechanisms that modulate ENaC function?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Ion channels, protein allostery, structure-function relationships, biophysics, evolution of function

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Electrophysiology, enzymology, molecular biology, structural modeling