Jane W. Marsh, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Can the composition of the gut microbiome identify patients at risk of clinical infection?

Can integration of bacterial genomics and mining of the electronic medical record enhance hospital outbreak detection?

Can 16S sequencing of peri-rectal swabs be used for surveillance of important drug resistant bacteria that are serious clinical and public health threats?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Genomic epidemiology
High-throughput whole genome sequencing
Bacterial genomics
Microbiome
Precision medicine

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Molecular epidemiologic detection of hospital-associated bacterial outbreaks
Comparative whole genome sequence analysis of bacterial genomes
Development of bioinformatics to generate reports describing comparative whole genome analyses for hospital infection prevention
Development of molecular assays to detect and track drug-resistant, hospital-acquired bacteria
Establishment of a local database and phylogeny of bacterial genomes specific to UPMC that can be used to monitor and track emergence and evolution of important bacterial pathogens
Capacity to grow and characterize anaerobic bacteria from the gut including Clostridium difficile