Christopher O'Donnell, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Can we reduce inflammation and prevent hyperglycemia early in the course of sepsis by administering small amounts of dextrose intragastrically?

Will long-term exposure to altitude improve glucose disposal in obese individuals?

Does disruption of sleep worsen outcomes after myocardial infarction?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Sleep; metabolism; integrative physiology; control of breathing; cardiovascular

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Chronically instrumented and tethered mice (vascular catheters, gastric cannulas, EKG, polysomnography, diaphragmatic EMG)

Murine heart failure models (coronary artery ligation, pulmonary artery and aortic banding)

Murine models of sepsis (LPS, cecal ligation and puncture, pneumonia)

Metabolism (hyperinsulinemic euglycemic clamps, frequently sampled intravenous glucose tolerance test)

Mouse lung transplant