Anuradha Ray, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Is the immune response in severe asthma different from that in milder asthma?
What are the molecular mechanisms underlying poor response to corticosteroids in severe asthma?
What is the role of immunometabolism in immune tolerance versus inflammation?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Immune response in severe vs milder asthma
Corticosteroid resistance
Immune tolerance
Dendritic cell-T cell interactions in lung immune responses
Mitochondrial regulation of immune responses in the respiratory mucosa

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Mouse models of asthma-severe and mild; Mouse models of airway tolerance; Flow cytometry and imaging cytometry; Pulmonary Function Test (Flexivent); RNA-seq, imaging, molecular biology and Seahorse assays for analysis of models.

COLLABORATORS:
Drs. Sally Wenzel, Prabir Ray, Jay Kolls, Sruti Shiva, Claudette St. Croix, Simon Watkins