Iain Scott, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
How does protein lysine acetylation regulate mitochondrial function?

How does lysine acetylation regulate changes in energy substrate utilization in heart failure?

How does overfeeding promote mitochondrial dysfunction in metabolic diseases?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Mitochondria; acetylation; bioenergetics; heart failure; metabolic disease

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Biochemical assays of protein acetylation
Mouse models of mitochondrial protein acetylation, heart failure and diabetes
Bioenergetic analyses of mitochondrial function
Cell-based assays of mitophagy and autophagy