Nic Sluis-Cremer, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Will the reversal of HIV latency in resting CD4+ T cell subsets lead to a cure for HIV infection?

Can we predict response to HIV antiretroviral treatment and the transmission patterns of drug-resistant variants by studying resistance and cross-resistance pathways?

Can we develop novel antiviral or antimicrobial agents that are active against drug-resistant variants?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Antiviral and antimicrobial therapy; drug resistance; drug discovery; retrovirology; structure-function relationships

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Biochemical/biophysical analyses of proteins; assay development and high throughput screening; single molecule fluorescence; genotypic and phenotypic analyses of drug resistance; primary cell models of HIV latency