Adam C. Straub, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
How do vascular cells communicate with each other to regulate blood flow and pressure?

Can we identify new targets and mechanisms that control blood vessel function?

How do Systemic and Pulmonary Hypertension, Sickle Cell Disease, Metabolic disease and Alzheimer’s disease impact vascular function?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Blood vessel • Nitric oxide • Hemoglobin • Cyclic nucleotides • Cytochrome B5 reductase 3

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Human polymorphisms and biomarker analysis
Generation of cardiovascular cell-type specific knockout and transgenic animals
Pressure/Wire myography and radiotelemetry for rodent blood pressure analysis
Cellular, Molecular and Biochemical Approaches to manipulate gene and protein expression in cells and tissues
Structure-function relationships for development of small molecule inhibitors