Prithu Sundd, PhD

Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
Identify the molecular mechanism of platelet-neutrophil aggregation in Sickle Cell Disease.

Identify the molecular mechanism of acute lung injury in Sickle Cell Disease.

Identify the molecular mechanism of pulmonary arteriole thrombosis in Sickle Cell Disease.

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Sickle Cell Disease • Vaso-occlusion • Acute Chest Syndrome • Neutrophils • Platelets.

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:
Intravital multi-photon excitation fluorescence microscopy in live mice.
Ex vivo microfluidic studies with patient blood.
In vitro fluorescence microscopic approaches (total internal reflection fluorescence, structured illumination and confocal microscopy).
Modeling pulmonary vaso-occlusion, acute chest syndrome and pulmonary thrombosis in transgenic SCD mice.
Image processing.